Parkinson's Disease Molecular and Therapeutic Insights From Model Systems Nass

Parkinson's DiseaseMolecular and Therapeutic Insights From Model Systems\nAuthor(s): Richard Nass, Serge Przedborski\nFormat: Hardback\nPublisher: Elsevier Science Publishing Co Inc, United States\nImprint: Academic Press Inc\nISBN-13: 9780123740281, 978-0123740281\nSynopsis\nParkinsons disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well .