High-Throughput Analysis in the Pharmaceutical , Wang Paperback..

CRC Press

The ever-shortening timelines and the high costs of drug discovery and development have brought about the need for high throughput approaches to methods that are currently used in the pharmaceutical industry. Written by well-known contributors, this book systematically describes high-throughput analysis for the industry. Exploring advanced instrumentation and automated sample preparation, the text discusses various techniques, including HPLC, MALDI-MS, and LC-MS/MS methods. An emphasis is placed on the later stage of drug development and the book includes discussions of topics such as pharmacokinetics. > The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corresponding revolutionary improvementx