Entropy and Free Energy in Structural Biology by Hagai Meirov... - 9780367427450

CRC Press

Entropy and Free Energy in Structural BiologyFrom Thermodynamics to Statistical Mechanics to Computer Simulation\nAuthor(s): Hagai Meirovitch\nFormat: Paperback\nPublisher: Taylor & Francis Ltd, United Kingdom\nImprint: CRC Press\nISBN-13: 9780367427450, 978-0367427450\nSynopsis\nComputer simulation has become the main engine of development in statistical mechanics. In structural biology, computer simulation constitutes the main theoretical tool for structure determination of proteins and for calculation of the free energy of binding, which are important in drug design. Entropy and Free Energy in Structural Biology leads the reader to the simulation technology in a systematic way. The book, which is structured as a course, consists of four parts: \n\nPart I is a short course on probability theory emphasizing (1) the distinction between the notions of experimental probability, probability space, and the experimental probability on a computer, and (2) elaborating on the mathematica.