Drug-Induced Liver Disease - 9780367446208

CRC Press

This book focuses on mechanisms of hepatotoxicity and reviews general principles of clinical presentation, histopathology, predisposition to toxicity, diagnosis, and management. It provides a systematic review of the major xenobiotics associated with drug-induced liver disease. > \nFeaturing more than 4100 references, Drug-Induced Liver Disease is an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines. This book supplies an in-depth discussion of drug-induced hepatoxicology, covering mechanisms, histopathology, management, risk factors, and patterns of drug and toxin-induced disease. It includes contributions international experts. > Part I: Mechanisms of Liver Injury 1. Drug-Induced Liver Disease 2. Cytochrome P450 Activation of Toxins and Hepatotoxicity 3. Antioxidant Defense in Liver Injury: Oxidant Stree