RAS Drug Discovery Past, Present and Future Gill Shokat Paperback Elsevier

RAS Drug Discovery\n\nPast, Present and Future\n\nA comprehensive technical overview of all the medicinal chemistry approaches in the public domain being deployed to target KRAS\n\nAdrian Gill (Edited by), Kevan M. Shokat (Edited by)\n\n9780443218613, Elsevier Science\n\nPaperback / softback, published 24 October 2024\n\n566 pages\n23.5 x 19 x 3.5 cm, 0.45 kg\n\nKRAS Drug Discovery: Past, Present and Future is a comprehensive overview of the state-of-the-art medicinal chemistry approaches towards targeting the formerly undruggable oncogene, KRAS. It includes Seminal medicinal chemistry case histories of KRASG12C inhibitors such as Sotorosib, the first approved KRASG12C inhibitor for NSCLC, alongside the latest advances towards identification of in vivo tools and development candidates targeting KRAS G12D, KRAS G13C and other mutations. The book also provides the reader with a comprehensive overview of the in vitro assay systems, in vivo pharmacology xenograft models and chemical biol]