Oxidative Stress and Neurodegenerative Disorders Qureshi Parvez Hardback

Oxidative Stress and Neurodegenerative DisordersAuthor(s): G. Ali Qureshi, S. Hasan Parvez\nFormat: Hardback\nPublisher: Elsevier Science & Technology, United Kingdom\nImprint: Elsevier Science Ltd\nISBN-13: 9780444528094, 978-0444528094\nSynopsis\nOxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provi.