Selection Bias and Covariate Imbalances in Randomized Clinica... - 9780470863626

Selection Bias and Covariate Imbalances in Randomized Clinical TrialsAuthor(s): Vance Berger\nFormat: Hardback\nPublisher: John Wiley & Sons Inc, United States\nImprint: John Wiley & Sons Inc\nISBN-13: 9780470863626, 978-0470863626\nSynopsis\nSelection bias can, and does, occur, even in randomized clinical trials. Steps need to be taken in order to ensure that this does not compromise the integrity of clinical trials; hence Selection Bias and Covariate Imbalances in Randomized Clinical Trials offers a comprehensive treatment of the subject and the methodology involved. This book: Provides an overview of the hierarchy of study designs, and justifies the position of randomised trials at the top of this hierarchy. Discusses the strengths and defects of randomisation, and provides real evidence to justify concern regarding its defects. Outlays the damaging consequences that selection bias causes when it does occur. Considers courses of action that can be taken to manage/ contain.