Applied Biophysics for Drug Discovery Huddler Hardback Wiley–Blackwell

Applied Biophysics for Drug DiscoveryAuthor(s): Donald Huddler, Edward R. Zartler\nFormat: Hardback\nPublisher: John Wiley & Sons Inc, United States\nImprint: John Wiley & Sons Inc\nISBN-13: 9781119099482, 978-1119099482\nSynopsis\nApplied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include:\nDesign considerations in biophysical-based lead screening\nThermodynamic characterization of p.