Platform Trial Designs in Drug Development - 9781138052451

CRC Press

Platform Trial Designs in Drug DevelopmentUmbrella Trials and Basket Trials\nAuthor(s): Zoran Antonijevic, Robert A. Beckman\nFormat: Hardback\nPublisher: Taylor & Francis Ltd, United Kingdom\nImprint: CRC Press\nISBN-13: 9781138052451, 978-1138052451\nSynopsis\nPlatform trials test multiple therapies in one indication, one therapy for multiple indications, or both. These novel clinical trial designs can dramatically increase the cost-effectiveness of drug development, leading to life-altering medicines for people suffering from serious illnesses, possibly at lower cost. Currently, the cost of drug development is unsustainable. Furthermore, there are particular problems in rare diseases and small biomarker defined subsets in oncology, where the required sample sizes for traditional clinical trial designs may not be feasible. \n\nThe editors recruited the key innovators in this domain. The 20 articles discuss trial designs from perspectives as diverse as quantum computing, patient.