Polycystic Kidney Disease - 9781138603899

CRC Press

Polycystic Kidney DiseaseAuthor(s): Jinghua Hu, Yong Yu\nFormat: Hardback\nPublisher: Taylor & Francis Ltd, United Kingdom\nImprint: CRC Press\nISBN-13: 9781138603899, 978-1138603899\nSynopsis\nThis volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies.\n\nKey Features\n\nExplores the role of cilia in polycystic kidney disease\nFocuses on myriad state-of-the-art methods and techniques\nReviews specific mutations integral to this autosomal genetic disease\nInclus