Neurodegeneration by Dennis Dickson, Roy O. Weller - 9781405196932

NeurodegenerationThe Molecular Pathology of Dementia and Movement Disorders\nAuthor(s): Dennis Dickson, Roy O. Weller\nFormat: Hardback\nPublisher: John Wiley and Sons Ltd, United Kingdom\nImprint: Wiley-Blackwell\nISBN-13: 9781405196932, 978-1405196932\nSynopsis\nMost textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells ([url] tau, ?-synuclein and TDP-43) and in the extracellular compartments ([url] ?-amyloid and prion proteins) or according to a share.