Inflammatory Bowel Disease: Genetics, Barrier Func tion, and Immunological Mech…

Inflammatory Bowel DiseaseGenetics, Barrier Function, and Immunological Mechanisms, and Microbial Pathways, Volume 1072\nAuthor(s): Wolfram W. Domschke, Martin F Kagnoff, Torsten F. Kucharzik, Lloyd Mayer, Stephan R. Targan\nFormat: Paperback\nPublisher: John Wiley and Sons Ltd, United Kingdom\nImprint: Wiley-Blackwell\nISBN-13: 9781573315685, 978-1573315685\nSynopsis\nInflammatory bowel disease (IBD), which encompasses both Crohn's disease and ulcerative colitis, is a chronically relapsing intestinal disorder that is characterized by diarrhea and abdominal pain. The incidence of IBD is increasing worldwide. Although some major advances have been made in recent years, the pathogenesis of the disease still remains obscure. As currently understood, a combination of genetic alterations and immunological disturbances causing an interaction of the enteric microflora with the underlying mucosa and a disrupted barrier function may be crucial for the development of disease.\nDespite substant.