Cyclic Peptides by Jesko Koehnke, James Naismith, Wilfred A v... - 9781782625285

Royal Society of Chemistry

Cyclic PeptidesFrom Bioorganic Synthesis to Applications\nAuthor(s): Jesko Koehnke, James Naismith, Wilfred A van der Donk\nFormat: Hardback\nPublisher: Royal Society of Chemistry, United Kingdom\nImprint: Royal Society of Chemistry\nISBN-13: 9781782625285, 978-1782625285\nSynopsis\nCyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have gained a lot of interest as alternative sources of new drugs to traditional small molecules. This book introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic approaches to their preparation. Following an introduction to cyclic peptides, biosynthetic and traditional chemical routes to cyclic peptides are reviewed. Due to their size, their synthesis is not trivial. Recent advances in the incorporation of novel structural units are presented in addition to how synthesis and biological methods can be combined. The chemical analysis of this molecular class is also discus.