Royal Society of Chemistry - Challenges in Biological Cryo Electron Microscopy - Faraday Discussion

Name: Royal Society of Chemistry - Challenges in Biological Cryo Electron Microscopy - Faraday Discussion
Brand: Royal Society of Chemistry

Royal Society of Chemistry

Challenges in Biological Cryo Electron MicroscopyFaraday Discussion 240\nAuthor(s): Royal Society of Chemistry\nFormat: Hardback\nPublisher: Royal Society of Chemistry, United Kingdom\nImprint: Royal Society of Chemistry\nISBN-13: 9781839164255, 978-1839164255\nSynopsis\nDevelopments in cryo-electron microscopy are creating new opportunities within structural biology and there is currently great interest in developing cryo-EM as a core tool for atomic level structural biology. Many structural techniques can give atomic or near atomic level information, but lack the ability to study proteins within a near-native environment, for example within a cellular compartment. Cryo-EM provides this opportunity, but despite the recent massive improvements in single particle cryo-EM, obtaining sub-2 structural information is still a major challenge. Cryo-electron microscopy has undergone significant developments in microscope design, camera technology and data processing regimes, but there are sM