Inflammatory Mechanisms in Mediating Hearing Loss by Leonard P. Rybak (2019, ...

Springer Nature Switzerland AG

Inflammatory Mechanisms in Mediating Hearing LossAuthor(s): Vickram Ramkumar, Leonard P. Rybak\nFormat: Paperback\nPublisher: Springer Nature Switzerland AG, Switzerland\nImprint: Springer Nature Switzerland AG\nISBN-13: 9783030064471, 978-3030064471\nSynopsis\nCommon forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of anti.