Drug Delivery in Dermatology: Fundamental and Practical (2021)

Drug Delivery in DermatologyFundamental and Practical Applications\nAuthor(s): Clia Luiza Petersen Vitello Kalil, Valria Campos\nFormat: Hardback\nPublisher: Springer Nature Switzerland AG, Switzerland\nImprint: Springer Nature Switzerland AG\nISBN-13: 9783030818067, 978-3030818067\nSynopsis\nSkin accounts for approximately 15% of an adults total body weight, with a surface of about 2m. It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals.\n\nThe topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, .