Theory, Techniques and Applications of Nanotech. Chandra, Nimesh<|

River Publishers > CRC Press

Theory, Techniques and Applications of Nanotechnology in Gene SilencingAuthor(s): Surendra Nimesh, Ramesh Chandra\nFormat: Hardback\nPublisher: River Publishers, Denmark\nImprint: River Publishers\nISBN-13: 9788792329837, 978-8792329837\nSynopsis\nGene silencing mediated through short interfering RNAs (siRNAs) is rapidly emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability in physiological conditions limits its therapeutic potential, hence there arises a need to develop a delivery system which can protect and efficiently transport siRNA to the target cells. Nanotechnology based non-viral vectors have been proposed as a potential alternate. Various polymeric nanoparticles have been shown as suitable delivery candidates with high cellular uptake efficiencies and advantage of reduced cytotoxicity. These delivery vectors form condensed complexes with siRNA which in turn provides protection to siRNA frox