New Advances in SHR Research - Pathophysiology , Mikhailov, Saito, Yamori, M..

CRC Press

This book deals with pathophysiology and pharmacology of spontaneously hypertensive rats (SHR) and describes new trends in SHR research from hemodynamic characteristics to immunological views. It is devoted to the use of tissue culture studies to elaborate SHR characteristics. > This book deals with pathophysiology and pharmacology of spontaneously hypertensive rats (SHR) and describes new trends in SHR research from hemodynamic characteristics to immunological views. It is devoted to the use of tissue culture studies to elaborate SHR characteristics. > 1. Pathophysiological overview of M-SHRSP 2. The development of hypertension in transgenic rats, TGR (mREN2) 27 3. Age-related immunological disorders in an animal model for hypertension, SHR rats 4. Increased production of nitric oxide in cultured aortic smooth muscle cells from SHR 5. Comparative enzyme histochemistry of NADPH-diaphorase (nitric oxide synthase) positive neurons in normal and spontaneously hypertensive rats 6. )