Genomic Uracil: Evolution, Biology, Immunology And Disease (New)

Genomic Uracil: Evolution, Biology, Immunology And DiseaseAuthor(s): Geir Slupphaug, Hans Einar Krokan\nFormat: Hardback\nPublisher: World Scientific Publishing Co Pte Ltd, Singapore\nImprint: World Scientific Publishing Co Pte Ltd\nISBN-13: 9789813233492, 978-9813233492\nSynopsis\nThis book describes genomic uracil in evolution, as a DNA constituent in adaptive and innate immune responses and as a mutagenic lesion causing cancer. Genomic uracil is as old as life and may have been a component in self-replicating molecules in the prebiotic era. The first living cells probably contained uracil in DNA, later to be replaced by thymine. The pioneering work of Nobel Laureate, Tomas Lindahl on spontaneous deamination of DNA cytosine to uracil was followed by his discovery of uracil-DNA glycosylase, which initiates repair of genomic uracil in base excision repair (BER). Uracil-DNA glycosylases are found in all forms of life and in DNA viruses, having roles in DNA repair, replication and epig.