Randomized Phase II Cancer Clinical Trials

Name: Randomized Phase II Cancer Clinical Trials
Brand: CRC Press

CRC Press

Randomized Phase II Cancer Clinical TrialsAuthor(s): Sin-Ho Jung\nFormat: Paperback\nPublisher: Taylor & Francis Ltd, United Kingdom\nImprint: Chapman & Hall/CRC\nISBN-13: 9780367576455, 978-0367576455\nSynopsis\nIn cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy.\n\nRandomized Phase II Cancer Clinical Trials explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase .