Bayesian Designs for Phase I-II Clinical Trials

Name: Bayesian Designs for Phase I-II Clinical Trials
Brand: CRC Press

CRC Press

Bayesian Designs for Phase I-II Clinical TrialsAuthor(s): Ying Yuan, Hoang Q. Nguyen, Peter F. Thall\nFormat: Hardback\nPublisher: Taylor & Francis Inc, United States\nImprint: Chapman & Hall/CRC\nISBN-13: 9781498709552, 978-1498709552\nSynopsis\nReliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. \n\nBayesian Designs for Phase III Clinical Trials describes how phase III designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human c.